Meta-analysis of the effects of oral and intravenous dexamethasone premedication in the prevention of paclitaxel-induced allergic reactions | Zendy

Fuchao Chen | Zendy; Linhai Wang | Zendy; Xiaoyu Zheng | Zendy; Xiumin Zhang | Zendy; Jun Zhang | Zendy; Linjun Li | Zendy

Open Access

Meta-analysis of the effects of oral and intravenous dexamethasone premedication in the prevention of paclitaxel-induced allergic reactions

Author(s) -

Fuchao Chen,

Linhai Wang,

Xiaoyu Zheng,

Xiumin Zhang,

Jun Zhang,

Linjun Li

Publication year - 2016

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.13705

Subject(s) - medicine , premedication , dexamethasone , regimen , meta analysis , paclitaxel , pharmacy , incidence (geometry) , surgery , chemotherapy , family medicine , physics , optics

Dexamethasone premedication is required to prevent paclitaxel-related hypersensitivity reactions (HSRs). Oral dexamethasone (PO-D) has been considered the standard premedication regimen. However, whether intravenous dexamethasone (IV-D) is feasible for preventing paclitaxel-related HSRs is still unclear. We conducted a meta-analysis to compare these two regimens.

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