Open AccessMeta-analysis of the effects of oral and intravenous dexamethasone premedication in the prevention of paclitaxel-induced allergic reactions
Author(s) -
Fuchao Chen,
Linhai Wang,
Xiaoyu Zheng,
Xiumin Zhang,
Jun Zhang,
Linjun Li
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.13705
Subject(s) - medicine , premedication , dexamethasone , regimen , meta analysis , paclitaxel , pharmacy , incidence (geometry) , surgery , chemotherapy , family medicine , physics , optics
Dexamethasone premedication is required to prevent paclitaxel-related hypersensitivity reactions (HSRs). Oral dexamethasone (PO-D) has been considered the standard premedication regimen. However, whether intravenous dexamethasone (IV-D) is feasible for preventing paclitaxel-related HSRs is still unclear. We conducted a meta-analysis to compare these two regimens.