Open AccessFGFR3, as a receptor tyrosine kinase, is associated with differentiated biological functions and improved survival of glioma patients
Author(s) -
Zheng Wang,
Chuanbao Zhang,
Lihua Sun,
Jingshan Liang,
Xing Liu,
Guanzhang Li,
Kun Yao,
Wei Zhang,
Tao Jiang
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.13139
Subject(s) - glioma , biology , receptor tyrosine kinase , cancer research , microarray analysis techniques , transcriptome , gene expression profiling , gene expression , receptor , gene , genetics
Activation of receptor tyrosine kinases is common in Malignancies. FGFR3 fusion with TACC3 has been reported to have transforming effects in primary glioblastoma and display oncogenic activity in vitro and in vivo. We set out to investigate the role of FGFR3 in glioma through transcriptomic analysis.