Genetic variants of MCP-1 and CCR2 genes and IgA nephropathy risk | Zendy

Jie Gao | Zendy; Xinghan Liu | Zendy; Linting Wei | Zendy; Dan Niu | Zendy; Jiali Wei | Zendy; Li Wang | Zendy; Heng Ge | Zendy; Meng Wang | Zendy; Qiaoling Yu | Zendy; Tianbo Jin | Zendy; Tian Tian | Zendy; Zhijun Dai | Zendy; Rongguo Fu | Zendy

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Genetic variants of MCP-1 and CCR2 genes and IgA nephropathy risk

Author(s) -

Jie Gao,

Xinghan Liu,

Linting Wei,

Dan Niu,

Jiali Wei,

Li Wang,

Heng Ge,

Meng Wang,

Qiaoling Yu,

Tianbo Jin,

Tian Tian,

Zhijun Dai,

Rongguo Fu

Publication year - 2016

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.12847

Subject(s) - nephropathy , gene , medicine , ccr2 , genetics , immunology , biology , bioinformatics , immune system , chemokine , diabetes mellitus , chemokine receptor , endocrinology

Monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 stimulate inflammation response by activating and recruiting monocytes/macrophages. MCP-1 and CCR2 polymorphisms were reported to be associated with various diseases. To explore the relationship between MCP-1 and CCR2 polymorphisms and IgA nephropathy (IgAN), we conducted this case-control study by enrolling 351 IgAN patients and 310 health controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate potential associations of MCP-1 and CCR2 polymorphisms with susceptibility and clinical parameters of IgAN. No statistical differences between IgAN group and the control group in the MCP-1 -2518 and CCR2 +190 genotypic groups were observed (P > 0.05). Individuals with MCP-1 -2518 GG genotypes had a higher blood pressure (GG vs. AA+AG: OR = 1.79, 95% CI = 1.07-2.99, P = 0.026) and Lee's grade (GG vs. AA+AG: OR = 2.05, 95% CI = 1.19-3.54, P = 0.009; GG vs. AA: OR = 2.24, 95% CI = 1.19-4.20, P = 0.01), compared with patients with AA/AG genotypes. A significant association between CCR2 +190 polymorphism and Lee's grades was observed (GA+AA vs. GG: OR = 2.66, 95% CI = 1.63-4.35, P < 0.001; GA vs. AA+GG: OR = 2.27, 95% CI = 1.39-3.70, P = 0.001). Our results indicated that MCP-1 and CCR2 polymorphisms may influence the progression of IgAN, but not increase/decrease its susceptibility.

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