Open AccessAssociation of vitamin D receptorFok Ipolymorphism with the risk of prostate cancer: a meta-analysis
Author(s) -
Shaosan Kang,
Yansheng Zhao,
Jian Liu,
Lei Wang,
Guang-Hui Zhao,
Xi Chen,
Anliang Yao,
Liguo Zhang,
Xiaojun Zhang,
Xiaoqiang Li
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.12837
Subject(s) - prostate cancer , medicine , meta analysis , calcitriol receptor , oncology , vitamin d and neurology , cancer
Several previous studies have been reported to examine the association between Vitamin D receptor (VDR) gene Fok I polymorphism and susceptibility to prostate cancer (PCa), however the results remain inconclusive. To provide a relatively comprehensive account of the association, we searched PubMed, Embase, CNKI, and Wanfang for eligible studies and carry out this meta-analysis. A total of 27 case-control studies with 10,486 cases and 10,400 controls were included. In the overall analysis, Fok I polymorphism was not significantly associated with the susceptibility to PCa. Subgroup analyses showed that significantly association was existed in Caucasian population, the subgroup of population-based controls and the stratified group with advanced tumor.These results indicate that the VDR Fok I polymorphism might be capable of causing PCa susceptibility and could be a promising target to forecast the PCa risk for clinical practice. However further well-designed epidemiologic studies are needed to confirm this conclusion.