Open AccessPrevalence of BRCA1/BRCA2 mutations in a Brazilian population sample at-risk for hereditary breast cancer and characterization of its genetic ancestry
Author(s) -
Gabriela Fernandes,
Rodrigo Augusto Depieri Michelli,
Henrique C R Galvão,
André Escremim de Paula,
Rui Pereira,
Carlos Andrade,
Paula Silva Felicio,
Cleonilson Protásio de Souza,
Deise R P Mendes,
Sáhlua Miguel Volc,
Gustavo Nóriz Berardinelli,
Rebeca Silveira Grasel,
Cristina S Sabato,
Danilo Vilela Viana,
Edmundo Carvalho Mauad,
Cristovam ScapulatempoNeto,
Banu K. Arun,
Rui Manuel Reis,
Edenir Inêz Palmero
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.12610
Subject(s) - breast cancer , genetics , germline mutation , proband , population , genetic testing , genetic genealogy , mutation , cancer , medicine , genetic counseling , biology , oncology , gene , environmental health
There are very few data about the mutational profile of families at-risk for hereditary breast and ovarian cancer (HBOC) from Latin America (LA) and especially from Brazil, the largest and most populated country in LA.