Positive association of collagen type I with non-muscle invasive bladder cancer progression | Zendy

Michael Brooks | Zendy; Qianxing Mo | Zendy; Ross Krasnow | Zendy; Philip Levy Ho | Zendy; YuCheng Lee | Zendy; Jing Xiao | Zendy; Antonina V. Kurtova | Zendy; Seth P. Lerner | Zendy; Gui Godoy | Zendy; Weiguo Jian | Zendy; Patricia Castro | Zendy; Fengju Chen | Zendy; David R. Rowley | Zendy; Michael Ittmann | Zendy; Keith Syson Chan | Zendy

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Positive association of collagen type I with non-muscle invasive bladder cancer progression

Author(s) -

Michael Brooks,

Qianxing Mo,

Ross Krasnow,

Philip Levy Ho,

YuCheng Lee,

Jing Xiao,

Antonina V. Kurtova,

Seth P. Lerner,

Gui Godoy,

Weiguo Jian,

Patricia Castro,

Fengju Chen,

David R. Rowley,

Michael Ittmann,

Keith Syson Chan

Publication year - 2016

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.12089

Subject(s) - bladder cancer , medicine , tumor progression , extracellular matrix , cancer , immunohistochemistry , type i collagen , pathology , proportional hazards model , oncology , biology , microbiology and biotechnology

Non-muscle invasive bladder cancers (NMIBC) are generally curable, while ~15% progresses into muscle-invasive cancer with poor prognosis. While efforts have been made to identify genetic alternations associated with progression, the extracellular matrix (ECM) microenvironment remains largely unexplored. Type I collagen is a major component of the bladder ECM, and can be altered during cancer progression. We set out to explore the association of type I collagen with NMIBC progression.

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