Open AccessPositive association of collagen type I with non-muscle invasive bladder cancer progression
Author(s) -
Michael Brooks,
Qianxing Mo,
Ross Krasnow,
Philip Levy Ho,
Yu-Cheng Lee,
Jing Xiao,
Antonina V. Kurtova,
Seth P. Lerner,
Gui Godoy,
Weiguo Jian,
Patricia Castro,
Ken Chen,
David R. Rowley,
Michael Ittmann,
Keith Syson Chan
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.12089
Subject(s) - bladder cancer , medicine , tumor progression , extracellular matrix , cancer , immunohistochemistry , type i collagen , pathology , proportional hazards model , oncology , biology , microbiology and biotechnology
Non-muscle invasive bladder cancers (NMIBC) are generally curable, while ~15% progresses into muscle-invasive cancer with poor prognosis. While efforts have been made to identify genetic alternations associated with progression, the extracellular matrix (ECM) microenvironment remains largely unexplored. Type I collagen is a major component of the bladder ECM, and can be altered during cancer progression. We set out to explore the association of type I collagen with NMIBC progression.