Androgen receptor mitigates postoperative disease progression of hepatocellular carcinoma by suppressing CD90+ populations and cell migration and by promoting anoikis in circulating tumor cells | Zendy

HsuehChou Lai | Zendy; Chun-Chieh Yeh | Zendy; LongBin Jeng | Zendy; Shang-Fen Huang | Zendy; Pei-Ying Liao | Zendy; Fu-Ju Lei | Zendy; Wei-Chun Cheng | Zendy; Cheng-Lung Hsu | Zendy; Xiujun Cai | Zendy; Chawnshang Chang | Zendy; WenLung Ma | Zendy

Open Access

Androgen receptor mitigates postoperative disease progression of hepatocellular carcinoma by suppressing CD90+ populations and cell migration and by promoting anoikis in circulating tumor cells

Author(s) -

HsuehChou Lai,

Chun-Chieh Yeh,

LongBin Jeng,

Shang-Fen Huang,

Pei-Ying Liao,

Fu-Ju Lei,

Wei-Chun Cheng,

Cheng-Lung Hsu,

Xiujun Cai,

Chawnshang Chang,

WenLung Ma

Publication year - 2016

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.10186

Subject(s) - medicine , hepatocellular carcinoma , oncology , metastasis , cancer , androgen receptor , cancer research , prostate cancer

Although hepatectomy and liver transplantation surgery for hepatocellular carcinoma (HCC) are effective treatment modalities, the risk of recurrence remains high, particularly in patients with a high number of circulating tumor cells (CTCs) expressing cancer stem/progenitor cell markers. Androgen receptor (AR) signaling has been shown to suppress HCC metastasis in rodent models of HCC. In this study, we investigated whether AR is associated with postoperative HCC recurrence.

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