Open AccessAndrogen receptor mitigates postoperative disease progression of hepatocellular carcinoma by suppressing CD90+ populations and cell migration and by promoting anoikis in circulating tumor cells
Author(s) -
Hsueh Chou Lai,
Chun Chieh Yeh,
Long Bin Jeng,
Shang Huang,
Pei Ying Liao,
Lei Fu,
Cheng Wei,
Cheng Lung Hsu,
Xiujun Cai,
Chawnshang Chang,
Wen Lung
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.10186
Subject(s) - medicine , hepatocellular carcinoma , oncology , metastasis , cancer , androgen receptor , cancer research , prostate cancer
Although hepatectomy and liver transplantation surgery for hepatocellular carcinoma (HCC) are effective treatment modalities, the risk of recurrence remains high, particularly in patients with a high number of circulating tumor cells (CTCs) expressing cancer stem/progenitor cell markers. Androgen receptor (AR) signaling has been shown to suppress HCC metastasis in rodent models of HCC. In this study, we investigated whether AR is associated with postoperative HCC recurrence.