Open AccessChloroquine suppresses proliferation and invasion and induces apoptosis of osteosarcoma cells associated with inhibition of phosphorylation of STAT3
Author(s) -
Chenglong Chen,
Hongliang Zhang,
Yan Yu,
Qingshan Huang,
Wei Wang,
Jianfang Niu,
Jingbing Lou,
Tingting Ren,
Yi Huang,
Wei Guo
Publication year - 2021
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.203196
Subject(s) - osteosarcoma , apoptosis , phosphorylation , cancer research , stat3 , chloroquine , cell growth , chemistry , microbiology and biotechnology , biology , immunology , biochemistry , malaria
Osteosarcoma (OS) is characterized by a high rate of metastasis. It has been found that tumor cells can bypass apoptosis which leads to an uncontrolled proliferation, but chloroquine (CQ) can have an effect on the tumors by inducing apoptosis. We aimed to explore the effects and the hypothetical mechanism of CQ effects on OS.