Open AccessCircular RNA circitga7 accelerates glioma progression via miR-34a-5p/VEGFA axis
Author(s) -
Ling Qi,
Weiyao Wang,
Guifang Zhao,
Hong Jiang,
Yu Zhang,
Donghai Zhao,
Hong Jin,
Haojun Yu,
Haidong Xu
Publication year - 2021
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.202996
Subject(s) - glioma , circular rna , microrna , vascular endothelial growth factor a , rna , cancer research , vegf receptors , biology , genetics , vascular endothelial growth factor , gene
Circular RNAs (circRNAs) are a group of noncoding RNAs derived from back-splicing events. CircRNA is reported to be involved in various tumor progressions, including glioma. Although there are a few reports of circular RNAs participating in gliomas, it is still unclear whether circular RNAs regulate the occurrence of gliomas. In our research, we found that the expression of circITGA7 in glioma tissues and glioma cells increased significantly. Knocking down circITGA7 can significantly inhibit the proliferation of glioma cells and reduce cell metastasis. Through analysis and dual-luciferase report assay, we found that circITGA7 acts as a sponge for miR-34a-5p targeting VEGFA in glioma. Our study showed that circITGA7 regulates the proliferation and metastasis of glioma cell lines (SW1783&U373) by regulating the miR-34a-5p/VEGFA pathway. In conclusion, our study revealed a regulatory loop for the circITGA7/miR-34a-5p/VEGFA axis to regulate glioma development.