Open AccessPDGFR-β+ fibroblasts deteriorate survival in human solid tumors: a meta-analysis
Author(s) -
Guoming Hu,
Liming Huang,
Kefang Zhong,
Meng Li,
Feng Xu,
Shimin Wang,
Tao Zhang
Publication year - 2021
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.202952
Subject(s) - cancer research , platelet derived growth factor receptor , oncology , medicine , receptor , growth factor
Fibroblasts are a highly heterogeneous population in tumor microenvironment. PDGFR-β + fibroblasts, a subpopulation of activated fibroblasts, have proven to correlate with cancer progression through multiple of mechanisms including inducing angiogenesis and immune evasion. However, the prognostic role of these cells in solid tumors is still not conclusive. Herein, we carried out a meta-analysis including 24 published studies with 6752 patients searched from PubMed, Embase and EBSCO to better comprehend the value of such subpopulation in prognosis prediction for solid tumors. We noted that elevated density of intratumoral PDGFR-β + fibroblasts was remarkably associated with worse overall survival (OS) and disease-free survival (DFS) of patients. In subgroup analyses, the data showed that PDGFR-β + fibroblast infiltration considerably decreased OS in non-small cell lung cancer (NSCLC), breast and pancreatic cancer, and reduced DFS in breast cancer. In addition, increased number of PDGFR-β + fibroblasts appreciably correlated with advanced TNM stage of patients. In conclusion, PDGFR-β + fibroblast infiltration deteriorates survival in human solid tumors especially in NSCLC, breast and pancreatic cancer. Hence, they may offer a practicable prognostic biomarker and a potential therapeutic strategy for these patients.