Open AccessMendelian randomization as an approach to assess causal effects of inflammatory bowel disease on atrial fibrillation
Author(s) -
Laite Chen,
Guosheng Fu,
Chenyang Jiang
Publication year - 2021
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.202906
Subject(s) - mendelian randomization , genome wide association study , medicine , odds ratio , confounding , single nucleotide polymorphism , genetic association , inflammatory bowel disease , disease , genetics , biology , genetic variants , genotype , gene
Despite growing evidence indicating that patients with inflammatory bowel disease (IBD) have an increased risk of atrial fibrillation (AF), owing to the potential biases of confounding effects and reverse causation, the specific relationship between IBD and AF remains controversial. The aim of this study is to determine whether there is a causal effect of IBD on AF.