Open AccessmiR-224 aggravates cancer-associated fibroblast-induced progression of non-small cell lung cancer by modulating a positive loop of the SIRT3/AMPK/mTOR/HIF-1α axis
Author(s) -
Juan Zhang,
Lei Han,
Jing Yu,
Hui Li,
Qingfeng Li
Publication year - 2021
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.202803
Subject(s) - ampk , pi3k/akt/mtor pathway , lung cancer , cancer research , sirt3 , cancer , medicine , cancer associated fibroblasts , cancer cell , oncology , chemistry , microbiology and biotechnology , biology , signal transduction , sirtuin , kinase , protein kinase a , gene , biochemistry , acetylation
Cancer-associated fibroblast (CAF) is among the most important tumor-host microenvironment components by affecting tumor progression. This study explored the role of miR-224 in CAF-induced non-small cell lung cancer (NSCLC).