miR-224 aggravates cancer-associated fibroblast-induced progression of non-small cell lung cancer by modulating a positive loop of the SIRT3/AMPK/mTOR/HIF-1α axis | Zendy

Juan Zhang | Zendy; Lan Han | Zendy; Jing Yu | Zendy; Hui Li | Zendy; Qingfeng Li | Zendy

Open Access

miR-224 aggravates cancer-associated fibroblast-induced progression of non-small cell lung cancer by modulating a positive loop of the SIRT3/AMPK/mTOR/HIF-1α axis

Author(s) -

Juan Zhang,

Lan Han,

Jing Yu,

Hui Li,

Qingfeng Li

Publication year - 2021

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.202803

Subject(s) - ampk , pi3k/akt/mtor pathway , lung cancer , cancer research , sirt3 , cancer , medicine , cancer associated fibroblasts , cancer cell , oncology , chemistry , microbiology and biotechnology , biology , signal transduction , sirtuin , kinase , protein kinase a , gene , biochemistry , acetylation

Cancer-associated fibroblast (CAF) is among the most important tumor-host microenvironment components by affecting tumor progression. This study explored the role of miR-224 in CAF-induced non-small cell lung cancer (NSCLC).

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