Open AccessMembrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma
Author(s) -
Ya Peng,
Zhaoyu Zhang,
Ailing Zhang,
Changhong Liu,
Yingnan Sun,
Zixuan Peng,
Yang Liu
Publication year - 2021
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.202793
Subject(s) - chromosomal translocation , cytoplasm , metastasis , annexin , cancer research , annexin a2 , colorectal cancer , carcinoma , medicine , oncology , biology , pathology , microbiology and biotechnology , cancer , biochemistry , staining , gene
Annexin A4 (ANXA4) is a Ca 2+ - and phospholipid-binding protein that belongs to the annexin family, which is involved in the development of multiple tumour types via NF-κB signalling. In this study, we verified the high expression and membrane-cytoplasm translocation of ANXA4 in colorectal carcinoma (CRC). Calcium/calmodulin-dependent protein kinase II gamma (CAMK2γ) was found to be important for high ANXA4 expression in CRC, whereas carbonic anhydrase (CA1) promoted ANXA4 aggregation in the cell membrane. An increased Ca 2+ concentration attenuated the small ubiquitin-like modifier (SUMO) modification of cytoplasmic ANXA4 and ANXA4 stabilization, and relatively high expression of ANXA4 promoted CRC tumorigenesis and epithelial-mesenchymal transition (EMT).