Open Accessβ cell aging and age-related diabetes
Author(s) -
Min Zhu,
Xiaohong Liu,
Wen Li,
Yanrong Liu,
Jun Cheng,
Younan Chen
Publication year - 2021
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.202593
Subject(s) - type 2 diabetes , diabetes mellitus , insulin resistance , senescence , pathogenesis , medicine , viewpoints , bioinformatics , gerontology , biology , endocrinology , art , visual arts
Type 2 diabetes is characterized by insulin resistance and loss of β cell mass and function. Aging is considered as a major risk factor for development of type 2 diabetes. However, the roles of pancreatic β cell senescence and systemic aging in the pathogenesis of type 2 diabetes in elderly people remain poorly understood. In this review, we aimed to discuss the current findings and viewpoints focusing on β cell aging and the development of type 2 diabetes.