Open AccessRNA-seq reveals the diverse effects of substrate stiffness on epidermal ovarian cancer cells
Author(s) -
Xiaoxu Yang,
Guohui Wang,
Xiaolei Huang,
Min Cheng,
Yangyang Han
Publication year - 2020
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.103906
Subject(s) - ovarian cancer , substrate (aquarium) , cancer research , rna , cancer , biology , computational biology , medicine , genetics , gene , ecology
Increasing evidence has confirmed that ovarian cancer is a mechanically responsive tumor both in vivo and in vitro . However, an understanding of the complete molecular mechanism involved in the response to substrate stiffness is lacking, as the associated transcriptome-wide effects have not been mapped. This limited understanding has restricted the identification of potential mechanically responsive targets in ovarian cancer.