MeCP2 inhibits cell functionality through FoxO3a and autophagy in endothelial progenitor cells | Zendy

Siyuan Zha | Zendy; Zhen Li | Zendy; Shuyan Chen | Zendy; Fang Liu | Zendy; Fei Wang | Zendy

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MeCP2 inhibits cell functionality through FoxO3a and autophagy in endothelial progenitor cells

Author(s) -

Siyuan Zha,

Zhen Li,

Shuyan Chen,

Fang Liu,

Fei Wang

Publication year - 2019

Publication title -

aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.473

H-Index - 90

ISSN - 1945-4589

DOI - 10.18632/aging.102183

Subject(s) - autophagy , microbiology and biotechnology , chromatin immunoprecipitation , biology , chemistry , promoter , gene expression , apoptosis , biochemistry , gene

Autophagy is an evolutionarily conserved intracellular degradation mechanism in which cell constituents are phagocytosed to maintain cellular homeostasis. Forkhead box O 3a (FoxO3a) promotes autophagy to protect cells from environmental stress. Methylated CpG binding protein 2 (MeCP2) is a nuclear protein that binds DNA and represses transcription. However, the mechanism and interplay between FoxO3a and MeCP2 underlying endothelial progenitor cell (EPC) function are not fully understood.

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