Open AccessMeCP2 inhibits cell functionality through FoxO3a and autophagy in endothelial progenitor cells
Author(s) -
Siyuan Zha,
Zhen Li,
Shuyan Chen,
Fang Liu,
Fei Wang
Publication year - 2019
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.102183
Subject(s) - autophagy , microbiology and biotechnology , chromatin immunoprecipitation , biology , chemistry , promoter , gene expression , apoptosis , biochemistry , gene
Autophagy is an evolutionarily conserved intracellular degradation mechanism in which cell constituents are phagocytosed to maintain cellular homeostasis. Forkhead box O 3a (FoxO3a) promotes autophagy to protect cells from environmental stress. Methylated CpG binding protein 2 (MeCP2) is a nuclear protein that binds DNA and represses transcription. However, the mechanism and interplay between FoxO3a and MeCP2 underlying endothelial progenitor cell (EPC) function are not fully understood.