Open AccessDown-regulation of long non-coding RNA MEG3 suppresses osteogenic differentiation of periodontal ligament stem cells (PDLSCs) through miR-27a-3p/IGF1 axis in periodontitis
Author(s) -
Yi Liu,
Chunpeng Liu,
Ankui Zhang,
Shichang Yin,
Ting Wang,
Yan Wang,
Meiming Wang,
Yixin Liu,
Qiaohui Ying,
Jian Sun,
Fulan Wei,
Dongxu Liu,
Chunling Wang,
Shaohua Ge
Publication year - 2019
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.102105
Subject(s) - periodontal ligament stem cells , meg3 , runx2 , microrna , periodontal fiber , alkaline phosphatase , chemistry , western blot , osteoblast , periodontitis , microbiology and biotechnology , gene expression , long non coding rna , biology , rna , gene , medicine , dentistry , biochemistry , in vitro , enzyme
This study aimed to investigate the roles of long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) in osteogenic differentiation of periodontal ligament stem cells (PDLSCs) in periodontitis.