
The differential spatiotemporal expression pattern of shelterin genes throughout lifespan
Author(s) -
Kay-Dietrich Wagner,
Yilin Ying,
Waiian Leong,
Jie Jiang,
Xuefei Hu,
Yi Chen,
JeanFrançois Michiels,
Yiming Lu,
Éric Gilson,
Nicole Wagner,
Jing Ye
Publication year - 2017
Publication title -
aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 90
ISSN - 1945-4589
DOI - 10.18632/aging.101223
Subject(s) - shelterin , telomere , biology , zebrafish , microbiology and biotechnology , gene expression , telomere binding protein , gene , genetics , dna binding protein , transcription factor
Shelterin forms the core complex of telomere proteins and plays critical roles in protecting telomeres against unwanted activation of the DNA damage response and in Emaintaining telomere length homeostasis. Although shelterin expression is believed to be ubiquitous for stabilization of chromosomal ends. Evidences suggest that some shelterin subunits have tissue-specific functions. However, very little is known regarding how shelterin subunit gene expression is regulated during development and aging. Using two different animal models, the mouse and zebrafish, we reveal herein that shelterin subunits exhibit distinct spatial and temporal expression patterns that do not correlate with the proliferative status of the organ systems examined. Together, this work shows that the shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development and aging.