Open AccessSynthesis, characterization and antimicrobial effect of Cu(ii) and Zn(ii) compounds derived from 1,2,4-triazoles
Author(s) -
Patrícia Saraiva Vilas Boas de Almeida,
José Roberto da Silveira Maia,
Mariana Caliman Falqueto,
Leandro Licursi de Oliveira
Publication year - 2022
Publication title -
the journal of engineering and exact sciences
Language(s) - English
Resource type - Journals
ISSN - 2527-1075
DOI - 10.18540/jcecvl8iss1pp13427-01-14e
Subject(s) - tetrahedral molecular geometry , trigonal bipyramidal molecular geometry , chemistry , octahedral molecular geometry , differential scanning calorimetry , infrared spectroscopy , thermogravimetric analysis , octahedron , melting point , metal ions in aqueous solution , metal , coordination geometry , crystallography , stereochemistry , inorganic chemistry , molecule , organic chemistry , crystal structure , hydrogen bond , thermodynamics , physics
Compounds of Cu(II) and Zn(II) with 3-R-1H-1,2,4-triazole-5-amine {R = methyl (mta), phenyl (pta)} were prepared and characterized by infrared spectroscopy (IR), multinuclear NMR (1H, 13C), electronic spectroscopy (UV-VIS), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), microanalyses and melting point. Dimeric, monomeric, and polymeric materials were synthesized in this work. The Zn(II)-1,2,4-triazole derivatives have the metal ion at the center of two geometric arrangements, being a tetrahedron for the complex-7 and 9, and an octahedron for the complex-8. The only polymeric material, complex-7, was characterized by the DSC analytical data. The Decomposition reaction of complex-8 in chloroform produced the complex-9, a aminoguanidine derivative, and the Zn(II)-benzoate compound. The IR and UV-VIS of Cu(II)-mta derivatives revealed two possible geometric patterns for the metallic ion; a distorted bipyramidal trigonal geometry for compounds 10 and 11 in solution, and in the solid state, the same geometry for complex-10, but for complex-11, the IR data suggest a distorted octahedral geometry. The biological assay of the 1,2,4-triazole compounds and their metal derivatives against Gram-positive and Gram-negative bacteria shown the compounds of Zn(II) as the only active materials with values of MIC within the range of 133.5 µM (83.3 µg / mL) to 360.7 µM (166.6 µg / mL).