Open AccessMTHFR GENE MUTATION AND ITS REPERCUSSION IN THE GENESIS AND TREATMENT OF DEPRESSION: CASE REPORT
Author(s) -
Alexandre Leal Laux,
Alana Klochinski,
Bruna Frigo Bobato,
Evelyn Suquebski Dib,
Harien Aline Sprung,
Jussara Mallmann,
Vitória Leticia Gomes Rota
Publication year - 2021
Publication title -
international journal of scientific research and management
Language(s) - English
Resource type - Journals
ISSN - 2321-3418
DOI - 10.18535/ijsrm/v9i07.mp03
Subject(s) - methylenetetrahydrofolate reductase , antidepressant , medicine , refractory (planetary science) , depression (economics) , psychiatry , oncology , gene , anxiety , genetics , allele , biology , macroeconomics , astrobiology , economics
This study aims to report the correlation of MTHFR gene mutation with the genesis of depression and antidepressants non-response in a patient, highlighting the importance of genetic investigation and indicating the replacement of L-methylfolate as an effective treatment adjuvant. This is a case report of a patient diagnosed with major depressive disorder, refractory to pharmacological therapies, in monotherapy or combination therapy, and psychotherapy. After 1 year and 4 months of persistent residual symptoms, genetic testing of the MTHFR gene was requested with confirmation of a heterozygous double mutation of MTHFR. This gene polymorphism can result in deficiency of L-methylfolate, which is related to psychiatric diseases and refractoriness to antidepressant therapy. With the introduction of l-methylfolate 15mg, the patient reported remission of depressive symptoms in 4 months of follow-up. MTHFR gene mutations influence the action of folate, favoring depression and leading to refractory response to conventional treatment.