Enhanced Wound Healing With Caloric Restriction, Refeeding, And Intermittent Fasting: Dietary Strategies In Support Of Bioproliferative Injection Therapies

Caloric restriction followed by re-feeding (CRRF), Intermittent fasting (IF) and ketogenic diets (KD) are known to be supportive of wound healing in animal models. Evidence also suggests that injections of bio-proliferative solutions (prolotherapy) in combination with functional range of motion exercises also promote tissue regeneration via wound healing mechanisms. Intermittent fasting and Ketogenic diets also favor wound healing, and may therefore synergistically support the regenerative effects of prolotherapy. A systemic review of Pubmed, Google Scholar, and other databases was conducted. Though no published sources directly linking these types of diets to an enhanced bio-proliferative injection response were identified, several studies did demonstrate that bio-regenerative responses of CRRF diets and prolotherapy share a common wound-healing pathway.  However, further research would be required to confirm and quantify if KD, CRRF, or IF diets are complimentary to prolotherapy.