Open AccessChitosan Nanoparticles Containing Cinnamomum verum J.Presl Essential Oil and Cinnamaldehyde; Preparation, Characterization and Anticancer Effects Against Melanoma and Breast Cancer Cells
Author(s) -
Kamyar Khoshnevisan,
Hiva Alipanah,
Hadi Baharifar,
Negar Ranjbar,
Mahmoud Osanloo
Publication year - 2022
Publication title -
traditional and integrative medicine
Language(s) - English
Resource type - Journals
eISSN - 2476-5112
pISSN - 2476-5104
DOI - 10.18502/tim.v7i1.9058
Subject(s) - cinnamaldehyde , chitosan , nanoparticle , essential oil , cinnamomum , chemistry , dynamic light scattering , nuclear chemistry , fourier transform infrared spectroscopy , materials science , nanotechnology , medicine , chemical engineering , chromatography , organic chemistry , cassia , alternative medicine , traditional chinese medicine , pathology , engineering , catalysis
Cancer is the second leading cause of death worldwide, and due to the emergence of resistance to synthetic drugs in different cancers, developing new green drugs have become crucial. In this study, chitosan nanoparticles containing Cinnamomum verum J.Presl essential oil and cinnamaldehyde (major ingredient) were first prepared. The obtained nanoparticles were then characterized using Dynamic Light Scattering (DLS), Transmission electron microscopy (TEM), and Attenuated Total Reflection-Fourier Transform InfraRed (ATR-FTIR). After that, anticancer effects of the as-prepared nanoparticles were investigated. IC50 values of chitosan nanoparticles containing the essential oil were observed at 79 and 112 µg/mL against A-375 and MDA-MB-468 cells, respectively. These values for chitosan nanoparticles containing cinnamaldehyde were obtained at 135 and 166 µg/mL. The results of the current study indicated that chitosan nanoparticles containing C. verum essential oil can inhibit the growth of human melanoma (A-375) and breast cancer (MDA-MB-468) cells.