Open AccessEffect of Particulate Properties of Inhaled Dry Powder Formulation on Bioavailability, Dissolution Rate of Drug Particles and Rate of Drug Removal from the Body
Author(s) -
Ali Alizadeh,
Hamed Hamishehkar,
Shadi Yaqoubi
Publication year - 2022
Publication title -
majallah-i dānishgāh-i 'ulūm-i pizishkī-i shahīd ṣadūqī yazd/majallah-i dānishgāh-i 'ulūm-i pizishkī va khadamāt-i bihdāshtī-darmānī shahīd ṣadūqī yazd
Language(s) - English
Resource type - Journals
eISSN - 2228-5741
pISSN - 2228-5733
DOI - 10.18502/ssu.v30i2.9276
Subject(s) - bioavailability , drug , medicine , inhalation , drug delivery , dissolution , pharmacology , pharmacokinetics , dissolution testing , particle size , dry powder inhaler , materials science , nanotechnology , chemical engineering , chemistry , anesthesia , inhaler , organic chemistry , asthma , biopharmaceutics classification system , engineering
The use of pulmonary drug delivery as a non-invasive drug delivery system for the systemic treatment of diseases as well as the topical treatment of respiratory diseases is increasing. Among the various inhaled formulations, inhaled dry powders show advantages over the other forms of inhaled medicines due to high stability, bioavailability and ease of use. The effect of particle properties on the rate of drug delivery to the lungs in inhaled dry powders has been investigated in previous papers.
Conclusion: Since the physicochemical properties of particles of dry powder inhalation formulations such as particle size, surface and particle shape, as well as the electrical charge of the particles play a decisive role in drug pharmacokinetics, in the present review article we intended to discuss the effect of these parameters of inhaled dry powder formulations on bioavailability, dissolution rate of drug particles and the rate of drug clearance from the body.