Open AccessExperimental study: experimental evaluation of phospholipid system containing doxorubicin HCL for use in chemotherapy
Author(s) -
Syed-Mohammad Moosavizadeh,
Morteza Baghiani,
Mohammad Majdizadeh,
Fateme Haghiralsadat,
Seyed-Mahmoud Moosavizadeh
Publication year - 2019
Publication title -
majallah-i dānishgāh-i 'ulūm-i pizishkī-i shahīd ṣadūqī yazd/majallah-i dānishgāh-i 'ulūm-i pizishkī va khadamāt-i bihdāshtī-darmānī shahīd ṣadūqī yazd
Language(s) - English
Resource type - Journals
eISSN - 2228-5741
pISSN - 2228-5733
DOI - 10.18502/ssu.v26i11.548
Subject(s) - liposome , zeta potential , doxorubicin , drug , drug delivery , phospholipid , phosphatidylcholine , medicine , drug carrier , pharmacology , cancer chemotherapy , chromatography , nuclear chemistry , nanotechnology , chemotherapy , materials science , chemistry , membrane , surgery , biochemistry , nanoparticle
Introdution: Common cancer treatment methods have many side effects. Therefore, the use of new methods for drug delivery to cancer cells is necessary. In the present study, nano formulations of lipid carriers containing doxorubicin have been synthesized and its physicochemical properties have been investigated.
Methods: The present study was an experimental study. The liposomal systems were synthesized by the method of thin-film hydration and using Tween-20, cholesterol and soybean phosphatidylcholine. After loading Doxorubicin drug into the liposomes, physiochemical properties of nano-carriers were determined from the perspective of encapsulation efficiency, drug release profile under healthy and cancerous cells condition, hydrodynamic diameter, zeta potential, morphology and IR spectra.
Results: The liposomal system had 132.9 nm in diameter, the encapsulation 93.74% and -38.73±0.18mV zeta potential. The maximum release of drug from the nano-carrier under conditions 37°C, pH=7.4 and 42°C, pH=5.4 and 37°C, pH=5.4 after 72 hours was 36.54% and 74.18% and 55.9% respectively. SEM and IR assessments revealed spherical morphology and the absence of chemical interaction between nano-carrier and drug.
Conclusion: The result of this research indicates that the liposomal system, having the appropriate physiochemical properties, has not changed the chemical nature of drug and thus can be a suitable and semi-targeted carrier for doxorubicin