Open AccessA Case of Erythema Multiforme Caused by Sildenafil Plus Tramadol
Author(s) -
Amir Hossein Ghanbarzamani,
Ebrahim Salehifar,
Kaveh Kazemian
Publication year - 2021
Publication title -
pharmaceutical and biomedical research
Language(s) - English
Resource type - Journals
eISSN - 2423-4494
pISSN - 2423-4486
DOI - 10.18502/pbr.v7i1.7358
Subject(s) - medicine , dermatology , bulla (seal) , tramadol , skin biopsy , spongiosis , erythema multiforme , sildenafil , biopsy , pathology , anesthesia , analgesic , lung
In this report, we present a 29-year-old man who experienced EM five days after using sildenafil and tramadol. Based on clinical examination and history, the diagnosis of EM was made confirmed via skin biopsy, which found intra-epidermal bulla filled by fibrinous exudate, some mononuclear cells, and a few eosinophils. The spongiotic epidermis showed lichenoid interface dermatitis, eosinophilic spongiosis, and necrolysis, consistent with EM diagnosis. Fluocinolone, 0.025% ointment, was prescribed for the patient, and the lesions healed after two weeks of treatment.