Open AccessThe Effect of Resistance Training on Malondialdehyde and Protein Carbonyl Concentration in the Heart Tissue of Rats Exposed to Stanozolol
Author(s) -
Ayat Arjmand,
Bahram Abedi,
Seyed Ali Hosseini
Publication year - 2021
Publication title -
pharmaceutical and biomedical research
Language(s) - English
Resource type - Journals
eISSN - 2423-4494
pISSN - 2423-4486
DOI - 10.18502/pbr.v6i4.5112
Subject(s) - malondialdehyde , stanozolol , medicine , anabolism , endocrinology , saline , chemistry , oxidative stress
Background: Consumption of anabolic steroids causes damage to various tissues, including the heart.
Objectives: This study aimed to investigate the effect of Resistance Training (RT) on Malondialdehyde (MDA) and Protein Carbonyl (PC) in the heart tissue of rats exposed to stanozolol (S).
Methods: In this experimental study, 18 rats with the mean age of 8 weeks and weight range of 150 to 200 g were selected and divided into three groups of 6 rats: 1. Sham (normal saline consumption) (Sh), 2. S, and 3. S+RT. For 8 weeks, the S and S+RT groups received 5 mg/kg/d S, and the S+RT group performed 5 RT sessions per week. Measurement of MDA and PC in the heart tissue was performed with the enzyme-linked immunosorbent assay.
Results: Stanozolol had a significant effect on increasing MAD (P=0.001) and PC (P=0.03) in the heart tissue. However, RT led to a decrease in MDA and PC in the heart tissue of rats exposed to S (P=0.001).
Conclusion: It appears that S consumption leads to an increase in MDA and PC levels in the heart tissue, while RT can improve the elevated levels of MDA and PC.