Open AccessImpact of Early Treatment with High-Dose Intravenous Immunoglobulin on Incidence of Kawasaki Disease Complications in Iranian Children
Author(s) -
Alireza Karimi Yazdi,
Parvin Akbariasbagh,
Yahya Aghighi,
Seyyed Reza Raeeskarami,
Toomaj Khadije,
Sahar Heidari,
Alamdari Shahnaz,
Leyla Sahebi
Publication year - 2021
Publication title -
journal of family and reproductive health./journal of family and reproductive health
Language(s) - English
Resource type - Journals
eISSN - 1735-8949
pISSN - 1735-9392
DOI - 10.18502/jfrh.v15i4.7890
Subject(s) - medicine , kawasaki disease , coronary artery aneurysm , incidence (geometry) , sensorineural hearing loss , aneurysm , artery , retrospective cohort study , coronary artery disease , pediatrics , hearing loss , surgery , audiology , physics , optics
Objective: Kawasaki disease (KD) occurs in five-year-old or younger children. This study aimed to evaluate the impact of high-dose intravenous immunoglobulin plus acetylsalicylic acid therapy on the prevention and treatment of coronary artery lesions and to evaluate the impact of high-dose acetylsalicylic acid (ASA) on the hearing of the patients.
Materials and methods: In this retrospective cohort study, 31 patients with KD were followed from January 2012 to December 2015. The clinical, para-clinical, color Doppler echocardiogram and audiometry results were evaluated.
Results: Overall, seven cases (22.6%) developed coronary artery aneurysm (CAA) in the acute phase of the disease, of whom only two still had CAA at the end of the treatment (6%). One of the five children with CAA recovery had a delay in the onset of treatment and one of two patients with persistent CAA at the end of treatment was admitted within the first 10 days. There was no evidence-based abnormal liver biochemical test. None of the patients developed sensorineural hearing loss (SNHL) on audiometry tests conducted before and after treatment.
Conclusion: Recovery of coronary artery lesions was 71.43% after 28 days of the onset of treatment. The distribution of coronary artery aneurysm was not different in terms of the time of the treatment initiation (P-Value = 0.371). None of the children had a sensorineural hearing loss (SNHL) 48 hours and 4 weeks after treatment.