Open AccessEndometrial Serous Carcinoma Arising from Adenomyosis: A Clinico-Pathological Insight
Author(s) -
Amrita Talwar,
Prateek Behera,
Arvind Ahuja,
Bhaskar Sarkar,
Ravi Hari Phulware
Publication year - 2021
Publication title -
journal of family and reproductive health./journal of family and reproductive health
Language(s) - English
Resource type - Journals
eISSN - 1735-8949
pISSN - 1735-9392
DOI - 10.18502/jfrh.v15i2.6454
Subject(s) - adenomyosis , medicine , serous fluid , serous carcinoma , endometrial cancer , gynecology , carcinoma , malignancy , hysterectomy , endometrium , pathological , endometriosis , cancer , pathology , ovarian cancer
Objective: Endometrial cancer (EC) is the most commonly diagnosed malignancy and has the secondhighest mortality rate among gynecological cancers. Adenomyosis is well-known for abnormal uterine bleeding and is a widely reported entity; however, an EC arising from the adenomyosis is a rare event; even rarer is the occurrence of serous endometrial carcinoma.
Case report: A 60-year post-menopausal female presented with post-menopausal bleeding. Subsequently, she underwent a hysterectomy, which showed atrophic and cystic endometrium with extensive adenomyosis and atypical endometrial glands, which are diffusely P53 positive with intervening negative benign and focally positive dysplastic endometrial glands. A final diagnosis of serous endometrial carcinoma arising from adenomyosis was rendered. In a table format, previously reported serous endometrial carcinoma Arising cases from adenomyosis using PubMed search had been described.
Conclusion: Serous endometrial carcinoma arising from adenomyosis (<20 cases reported) and has a slightly more dismal prognosis than those deriving from the endometrial cavity. Hence, this case report highlights the occurrence, rarity, and importance of such an entity.