Open AccessSurvival Analysis of Patients with Brain Stroke in the Presence of Competing Risks: A Weibull Parametric Model
Author(s) -
Solmaz Norouzi,
Ramazan Fallah,
A. Pourdarvish,
Seyed Morteza Shamshirgaran,
Farshid Farzipoor,
Mohammad Asghari Jafarabadi
Publication year - 2021
Publication title -
journal of biostatistics and epidemiology
Language(s) - English
Resource type - Journals
eISSN - 2383-420X
pISSN - 2383-4196
DOI - 10.18502/jbe.v7i3.7295
Subject(s) - medicine , hazard ratio , stroke (engine) , confidence interval , proportional hazards model , odds ratio , mechanical engineering , engineering
This study aimed to assess the association between the survival of patients and outcomes in Brain Stroke (BS) in the presence of competing risks utilizing a Weibull parametric model.
Methods: In this longitudinal study, 332 patients with BS were attended from Imam Khomeini Hospital in Ardabil, Iran. The stroke was diagnosed according to the medical history, current symptoms, and brain imaging during June 2008 and 2018. The survival of the patients, as the primary outcome, was modeled utilizing the best-chosen Weibull model in the presence of competing risks, including stroke and other factors (heart disease, blood pressure, etc.).
Results: Older age at diagnosis (59-68 years: hazard ratio [HR]=2.27; 90% confidence interval [CI]: 1.65 to 3.12; 69-75 years: HR=4.79; 95% CI: 3.56 to 6.44; ≥76 years: HR, 4.92; 95% CI: 3.55 to 6.80), being a male (HR, 1.39; 95% CI: 1.11 to 1.75), being unemployed (HR, 1.44; 95% CI: 1.39 to 1.82), having heart disease (HR, 1.68; 95% CI: 1.38 to 2.06), and hemorrhagic stroke (HR, 2.21; 95% CI: 1.378to 2.75) were directly related to death from BS. Older age at diagnosis (59-68 years: HR, 18.01; 90% CI, 5.33 to 64.92; 75-69 years: HR, 18.56; 95% CI: 6.97 to 86.57; ≥76 years: HR, 28.90; 95% CI: 15.77 to 218.49), and urban residence (HR, 0.46; 90% CI, 0.28 to 0.77) were directly related to death from other causes.
Conclusion: The recognition of the influential factors on the mortality of BS patients can allow increasing their survival.