Open AccessCan Neutrophil-lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis?
Author(s) -
Tevfik Kalelioğlu,
Guler Celikel,
Özlem Devrim Balaban,
Nesrin Karamustafalıoğlu,
J. Kim Penberthy
Publication year - 2021
Publication title -
iranian journal of psychiatry.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.503
H-Index - 17
eISSN - 2008-2215
pISSN - 1735-4587
DOI - 10.18502/ijps.v16i3.6264
Subject(s) - leukocytosis , etiology , systemic inflammation , neutrophil to lymphocyte ratio , medicine , neuroleptic malignant syndrome , inflammation , lymphocyte , immunology , pathology
Objective: Neuroleptic malignant syndrome (NMS) is a rare but severe side effect of antipsychotic medication. Neutrophil-lymphocyte ratio (NLR) is a simple marker used to measure systemic inflammation.
Method: In this case report we explore the relationship of inflammation in the etiology of NMS. In our case involving NMS, although there was no leukocytosis, the NLR was increased up to systemic infection levels.
Conclusion: We hypothesized that systemic inflammation may take a role in developing NMS. If so, NLR could be a new marker of NMS that may be able to provide more sensitive results than leukocyte levels.