Open AccessIncreased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis
Author(s) -
Fatemeh Esfahanian,
Mojgan Mirabdolhagh Hazaveh,
Laya Hooshmand Garehbagh,
Kowsar Falahati,
Mitra Ataei,
Mohammad Hossein Sanati,
Zohreh Jadali
Publication year - 2021
Publication title -
iranian journal of public health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 39
eISSN - 2251-6093
pISSN - 2251-6085
DOI - 10.18502/ijph.v50i8.6817
Subject(s) - mitochondrial dna , thyroiditis , oxidative stress , medicine , mitochondrion , peripheral blood , oxidative damage , oxidative phosphorylation , dna damage , immunology , pathophysiology , dna , pathology , biology , thyroid , genetics , biochemistry , gene
Background: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy controls (HC).
Methods: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto’s thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018.
Results: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group.
Conclusion: These data suggest the possible involvement of mitochondria and oxidative stress in the pathophysiology of HT.