Open AccessMethylation Assessment of Two DKK2 and DKK4 Genes in Oral Squamous Cell Carcinoma Patients
Author(s) -
Sedigheh Kheirandish,
Nosratollah Eshghyar,
Farzad Yazdani,
Pouyan Amini Shakib,
Ali Hosseini-Bereshneh,
Zahra Nouri,
Ali Kheiran-Dish,
Fatemeh Karami
Publication year - 2020
Publication title -
iranian journal of public health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 39
eISSN - 2251-6093
pISSN - 2251-6085
DOI - 10.18502/ijph.v49i10.4698
Subject(s) - methylation , dna methylation , gene , biology , carcinogenesis , wnt signaling pathway , promoter , cancer research , polymerase chain reaction , epigenetics , microbiology and biotechnology , bisulfite sequencing , bisulfite , gene expression , genetics
Oral squamous cell carcinoma (OSCC) is one of the most important types of oral malignancies. DKK gene family members as well as DKK2/4 have critical roles in regulation of Wnt signaling as one of the main determining pathway in oral carcinogenesis. This study aimed to identify promoter methylation status of DKK2/4 genes to provide possible biomarkers for early detection and treatment of OSCC patients.