Open AccessLeukocyte Behavior in Mesenteric Microcirculation upon Exper-imental By Leishmania Spp. in BALB/c Mice
Author(s) -
Herintha Coeto Neitzke-Abreu,
Rhuan Carlos Souza Caetano,
Kárin Rosi Reinhold-Castro,
Manoel Sebastião da Costa Lima-Júnior,
Wagner José Tenório dos Santos,
Gessilda de Alcântara Nogueira de Melo,
Roberto Kenji Nakamura Cuman,
Sandra Mara Alessi Aristides,
Thaís Gomes Verzignassi Silveira,
Maria Valdrinez Campana Lonardoni
Publication year - 2021
Publication title -
iranian journal of parasitology./iranian journal of parasitology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.477
H-Index - 27
eISSN - 2008-238X
pISSN - 1735-7020
DOI - 10.18502/ijpa.v16i4.7869
Subject(s) - leishmania , biology , microbiology and biotechnology , microcirculation , leishmania braziliensis , parasite hosting , leishmania mexicana , immunology , adhesion , leishmaniasis , cutaneous leishmaniasis , chemistry , medicine , organic chemistry , world wide web , computer science
Background: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice.
Methods: Five experimental groups were considered: group 1 (L. braziliensis); group 2 (L. amazonensis); group 3 (L. major); group 4 (control group with PBS); group 5 (negative control group), analyzed 3, 6, 12, and 24 h after parasite inoculation.
Results: Infections by the different Leishmania species caused an increase in the number of rolling leukocytes: L. braziliensis a peak at 6 h; L. amazonensis and L. major a peak at 3 h. The Leishmania infections induced leukocyte adhesion: L. major and L. amazonensis showed an increase after 3 and 6 h, respectively.
Conclusion: The kinetics of cellular recruitment in Leishmania infections, leading to infection susceptibility or resistance, indicates that distinct mechanisms regulate the initial response to Leishmania infection and determine its course.