Open AccessImmobilization of Clostridium perfringens type D in calcium alginate beads: toxin production mimics free cell culture
Author(s) -
Hakimeh Rakhshandeh,
Mehrdad Shamsaddini Bafti,
Behnaz Familsatarian,
Maryam Nooshadokht,
Payam Khazaeli,
Omid Raiesi,
Bagher Amirheidari
Publication year - 2022
Publication title -
iranian journal of microbiology.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.37
H-Index - 27
eISSN - 2008-4447
pISSN - 2008-3289
DOI - 10.18502/ijm.v14i4.10236
Subject(s) - clostridium perfringens , calcium alginate , sodium alginate , chemistry , lysis , chromatography , bacteria , microbiology and biotechnology , fermentation , glucuronic acid , calcium , sodium , biochemistry , biology , organic chemistry , polysaccharide , genetics
Cell-immobilization is used to maintain microbial culture to produce metabolites in repeated-batch or continuous fermentations, thereby reducing the time and resources spent on delivering mass production of microbe. The technique also enables shortening of the detoxification phase and the amount of formaldehyde required due to low incidence of viable bacteria in the extract.