Open AccessMassive Splenomegaly: A Rare Presentation of Megaloblastic Anemia
Author(s) -
Tahereh GholipurShahraki,
Alireza Sadeghi,
Padideh Oghab,
Pegah Farrokhi,
Azadeh Moghaddas
Publication year - 2021
Publication title -
international journal of hematology- oncology and stem cell research.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.436
H-Index - 16
eISSN - 2008-3009
pISSN - 2008-2207
DOI - 10.18502/ijhoscr.v15i2.6044
Subject(s) - megaloblastic anemia , pancytopenia , cobalamin , anemia , medicine , vitamin b12 , spleen , gastroenterology , bone marrow
Megaloblastic anemia is a common disorder with various manifestations. Of the many causes, cobalamin or folate deficiency can eventuate into megaloblastic anemia. It can lead to pancytopenia and mild to moderate splenomegaly, but massive splenomegaly rarely seen in this situation. We describe a 39-yearold woman with marked enlargement of the spleen and pancytopenia that was found to have megaloblastic anemia. The splenomegaly and blood count resolved 4 months after initiation of vitamin B12 therapy. It is important to know massive splenomegaly may occur in megaloblastic anemia, and although it is rare, bur can reversible with early treatment.