Open AccessThe Comparison of the Protective Effect of L-Carnitine, Chromium and Vitamin D with Metformin on Liver, Antioxidant Enzyme Activity, and Iron Metabolism in Diabetic Rats
Author(s) -
Parisa Sheikh Samani,
Kahin Shahanipour,
Ali Noori Diziche,
Mohammad Adibnejad
Publication year - 2021
Publication title -
iranian journal of diabetes and obesity
Language(s) - English
Resource type - Journals
eISSN - 2345-2250
pISSN - 2008-6792
DOI - 10.18502/ijdo.v13i2.6476
Subject(s) - metformin , medicine , carnitine , diabetes mellitus , chromium , antioxidant , endocrinology , vitamin e , vitamin c , vitamin , chemistry , biochemistry , organic chemistry
Objective: Due to the lack of information about the positive or negative effects of L-carnitine, chromium, vitamin D, and the uptake of a safe dietary supplement to reduce the effects of diabetes, it seems essential to determine the effects of these drugs on diabetes.
Materials and Methods: Wistar rats were divided into 12 groups, control, diabetic, and intact, each of which was treated with metformin, L-carnitine, vitamin D, and chromium or a combination of L-carnitine, vitamin D, and chromium. The serum levels of liver function parameters, iron, TIBC, Catalase and GPX activities were measured. Data were statistically analyzed by one-way ANOVA using SPSS 18 software. Statistical significance among the groups was determined using LSD test, and P-value< 0.05 was considered significant in all cases.
Results: AST activity in diabetic groups and those receiving chromium and L-carnitine has significantly reduced (P-value= 0.009). A significant reduction in ALT and ALP activity in the diabetic groups receiving vitamin D and combined and non-diabetic groups receiving metformin were observed, in contrast to a significant increase in ALT activity in diabetic recipients of Lcarnitine (P-value= 0.009).
Conclusion: L-carnitine, chromium, and vitamin D supplements have synergistic effects and a combination of them has the best protective effect on factors that have been studied.