Open AccessDelay in Diagnosis of Two Siblings with Severe Ocular Problems and Autoimmune Polyglandular Syndrome
Author(s) -
Samin Sharafian,
Marzieh Tavakol,
Mohammad Gharagozlou,
Nima Parvaneh
Publication year - 2020
Publication title -
iranian journal of allergy, asthma and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.357
H-Index - 25
eISSN - 1735-5249
pISSN - 1735-1502
DOI - 10.18502/ijaai.v19i3.3460
Subject(s) - chronic mucocutaneous candidiasis , medicine , hypoparathyroidism , dermatology , keratoconjunctivitis , photophobia , exon , frameshift mutation , immunology , disease , genetics , gene , ophthalmology , pathology , biology
Autosomal polyendocrinopathy syndrome type 1(APS1) is a scarce polyendocrinopathy with autosomal recessive inheritance results from defects in the human autoimmune regulatory (AIRE) gene. In addition to three major manifestations of APS1 including mucocutaneous candidiasis, hypoparathyroidism, and Addison’s disease, ophthalmic problems such as keratoconjunctivitis, dry eye, iridocyclitis, and cataract can be seen in these patients. In this article, we introduced two siblings presented with nail dystrophia, severe photophobia, and keratitis since early childhood which genetic examination revealed single nucleotide T>C translocation in their 2nd exon and heterozygous deletion mutation in their 12th exon.