Open AccessInvestigation of Auger Electron Emitting Radionuclides Effects in Therapy Using the Geant4-DNA Toolkit: A Simulation Study
Author(s) -
Parvin Ahmadi,
Mojtaba Shamsaei Zafar Ghandi,
Aliasghar Shokri
Publication year - 2021
Publication title -
frontiers in biomedical technologies
Language(s) - English
Resource type - Journals
eISSN - 2345-5837
pISSN - 2345-5829
DOI - 10.18502/fbt.v8i2.6511
Subject(s) - ionizing radiation , auger effect , electron , radionuclide , auger electron spectroscopy , auger , dna , radiation , yield (engineering) , atomic physics , absorbed dose , radiochemistry , physics , chemistry , materials science , nuclear physics , irradiation , biochemistry , thermodynamics
Purpose: The biological effects of ionizing radiation at the cellular and subcellular scales are studied by the number of breaks in the DNA molecule that provides a quantitative description of the stochastic aspects of energy deposition at cellular scales. The Geant4 code represents a suitable theoretical toolkit in microdosimetry and nanodosimetry. In this study, radiation effects due to Auger electrons emitting radionuclides such as 195mPt 113mIn, 125I and 201Tl are investigated using the Geant4-DNA.
Materials and Methods: The Geant4-DNA is the first Open-access software for the simulation of ionizing radiation and biological damage at the DNA scale. Low-energy electrons, especially Auger electron from Auger electron emitting radionuclides during the slowing-down process, deposit their energy within a nanometer volume.
Results: The average number of Single-Strand Breaks (SSB) and Double-Strand Breaks (DSB) of DNA as a function of energy and distance from the center of the DNA axis are shown.
Conclusion: The highest DSBs yield has occurred at energies less than 1 keV, and induces a higher DSBs yield.