Open AccessInfluence of ascorbic acid and α-tocopherol on the autoxidation and in vitro antifungal activity of amphotericin B
Author(s) -
Mohammed Habib Belhachemi,
Z. Boucherit-Otmani,
K. Boucherit,
Sara Belmir
Publication year - 2021
Publication title -
current medical mycology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.369
H-Index - 6
eISSN - 2423-3439
pISSN - 2423-3420
DOI - 10.18502/cmm.7.1.6178
Subject(s) - ascorbic acid , tbars , thiobarbituric acid , tocopherol , autoxidation , chemistry , antioxidant , lipid peroxidation , reactive oxygen species , biochemistry , vitamin e , food science
Amphotericin B (AmB) is the standard treatment for systemic fungal infections; however, the formation of reactive oxygen species reduces the efficacy and stability of this molecule. The present study aimed to evaluate the effect of the combination of AmB with ascorbic acid and α-tocopherol on its autoxidation and antifungal activity.