Open AccessCancer has an Independent Association with Death in Hospitalized Patients with COVID-19: A Single-center Study in Iran
Author(s) -
Reza Ghaletaki,
Kasra Kolahdouzan,
Saeid Rezaei,
Farzaneh Bagheri,
Fatemeh Jafari,
Mohammadreza Chavoshi,
Negin Mohammadi,
Monireh Sadat Seyyedsalehi,
Azin Nahvijou,
Nima Mousavi Darzikolaee,
Samaneh Salarvand,
Ali Kazemian,
Mahdi Aghili,
Kazem Zendehdel
Publication year - 2022
Publication title -
basic and clinical cancer research
Language(s) - English
Resource type - Journals
eISSN - 2228-6527
pISSN - 2228-5466
DOI - 10.18502/bccr.v13i1.8830
Subject(s) - medicine , cancer , logistic regression , comorbidity , intensive care unit , retrospective cohort study , multivariate analysis , cohort , covid-19 , univariate analysis , lung cancer , cohort study , disease , infectious disease (medical specialty)
Background: COVID-19 could cause severe complications in those with pre-existing conditions such as cancer. Here, we aimed to assess the outcome of COVID-19 in hospitalized patients with a history of cancer.
Methods: In this retrospective cohort study, we extracted medical records of patients with any cancer history among hospitalized patients with COVID-19. Our patients were admitted between February 20th and July 15th, 2020. The primary outcome was death, and the secondary outcomes were overall survival, COVID-19-specific mortality, admission to intensive care unit (ICU), and hospital stay. A group of individuals without cancer history was selected from the COVID-19 cohort and matched for age, gender, and pre-existing conditions. We utilized univariate and multivariate logistic regression to analyze the association between studied variables and primary outcomes.
Results: We identified 46 patients with cancer and COVID-19. The median age was 63, and 54.3% were male. According to the univariate logistic regression analysis, death was 5.3 (CI95%: 1.75-15.85) times more probable in cancer patients than controls (p=0.003). The multivariate analysis adjusted for having cancer and sex, age, and having any comorbidity showing this figure was 5.5 (CI95%:1.8-16.8) (p=0.003). The 30- and 90-day COVID-19 specific mortality was 30% (CI95%:17-43) and 33% (CI95%: 20-46), respectively.
Conclusion: Patients with COVID-19 with a history of cancer have a considerably higher risk of death irrespective of age, gender, and other pre-existing conditions. Patients with advanced cancers and concurrent bacterial infections need the most vigorous care.