Open AccessAntitumor Activities of Green Tea by Up-regulation of miR-181a Expression in LNCaP Cells Using 3D Cell Culture Model
Author(s) -
Fatemeh Safari,
Narjes Rayat Azad,
Ali Alizadeh Ezdiny,
Safoora Pakizehkar,
Zeinab Khazaei Koohpar,
Najmeh Ranji
Publication year - 2022
Publication title -
avicenna journal of medical biotechnology.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.399
H-Index - 22
eISSN - 2008-4625
pISSN - 2008-2835
DOI - 10.18502/ajmb.v14i1.8174
Subject(s) - lncap , microrna , apoptosis , cell growth , green tea , camellia sinensis , biology , cancer research , cell culture , cancer cell , gene expression , microbiology and biotechnology , cancer , gene , biochemistry , botany , food science , genetics
Prostate Cancer (PCa) is the major reason for the high mortality rates among men worldwide. In fact, current therapeutic approaches are not successful. It appears that discovering more effective methods considering several parameters such as availability, low cost, and no toxicity to normal cells is one of the biggest challenges for interested researchers. Green tea (extracted from the plant Camellia sinensis ) with high level of polyphenolic compounds and as the most globally consumed beverage has attracted considerable interest. MicroRNAs (or miRNAs) were considered as novel tools in cancer therapy which modulate various biological events in cell by regulation of gene expression. The aim of the current study was to evaluate the antitumor activity of green tea in LNCaP cells through up-regulation of miR-181a expression.