Open AccessSignificant Post-Chemotherapy Decrease of Ovarian Reserve in Iranian Women With Breast Cancer
Author(s) -
Bita Eslami,
Amirmohsen Jalaeefar,
Ashraf Moini,
Ramesh Omranipour,
Maryam Haghighi,
Sadaf Alipour
Publication year - 2020
Publication title -
acta medica iranica.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 27
eISSN - 1735-9694
pISSN - 0044-6025
DOI - 10.18502/acta.v58i8.4591
Subject(s) - medicine , fertility preservation , ovarian reserve , anti müllerian hormone , breast cancer , chemotherapy , fertility , premature ovarian failure , oncology , gynecology , ovarian cancer , cancer , hormone , infertility , population , pregnancy , environmental health , biology , genetics
Fertility preservation counseling has a high priority in young breast cancer (BC) patients. Cytotoxic chemicals used for chemotherapy in these patients increased the risk of premature ovarian failure. This study evaluated the anti-mullerian hormone (AMH) level at the time of diagnosis and within a month after the end of chemotherapy, while predicting the time of the return of ovarian function in BC cases (n=46) younger than 46 years for the first time in Iran. Cases were selected from those attending the breast oncology clinic of the two hospitals with a newly diagnosed in situ or invasive BC. The present study results showed AMH levels were significantly decreased in almost all women within a month after chemotherapy. It seems that the need for fertility preservation depends on patient age and baseline AMH level, but counseling should be offered by the clinician in young breast cancer patients.