Open AccessThe Role of Substance P in Neurodegenerative Diseases
Author(s) -
Atefeh Ghahremanloo,
Fariba Mohammadi,
Seyed Isaac Hashemy
Publication year - 2020
Publication title -
acta medica iranica.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 27
eISSN - 1735-9694
pISSN - 0044-6025
DOI - 10.18502/acta.v58i7.4416
Subject(s) - medicine , amyotrophic lateral sclerosis , neuroprotection , neuroscience , disease , multiple sclerosis , central nervous system , huntington's disease , pathogenesis , substance p , neurodegeneration , neuropeptide , nervous system , spinal cord , receptor , pathology , immunology , psychiatry , biology
- Tachykinins (TKs) are a family of neuropeptides widely distributed in the human body, especially in the nervous system. TKs have exhibited both neuroprotective and neurodegenerative properties in the central nervous system (CNS) and spinal cord. Also, several studies have shown that substance P (SP), as a pioneering neuropeptide of the TK family, is engaged in the pathogenesis of neurodegenerative disorders (NDs), such as Alzheimer disease, Multiple Sclerosis, Parkinson’s disease, Huntington’s disease, and Amyotrophic lateral sclerosis. However, a huge body of information available about the level of SP in NDs demonstrates that SP and its receptors might be prognostic or diagnostic factors for NDs. The present review article summarizes the roles of TKs in common neurodegenerative disorders.