Open AccessRegulatory Functions of MicroRNAs in Cancer Pathogenesis
Author(s) -
Mahafarin Maralani,
Behzad Baradaran,
Khalil Hajiasgharzadeh,
Marc Peeters
Publication year - 2021
Publication title -
acta medica iranica.
Language(s) - English
Resource type - Journals
eISSN - 1735-9694
pISSN - 0044-6025
DOI - 10.18502/acta.v58i11.5140
Subject(s) - microrna , gene , suppressor , cancer , metastasis , computational biology , medicine , regulation of gene expression , biology , gene expression , bioinformatics , cancer research , genetics
MicroRNAs (miRNAs) are a large family of evolutionary conserved small non-coding RNA molecules that firstly discovered in 1993. They regulate gene expression of about 50% of protein-coding genes at the post-transcriptional level. MiRNAs can target numerous messenger RNAs and subsequent misexpression of them can affect many different signaling pathways. They are playing a pivotal role in cancer development by regulation of the genes expression which involved in the proliferation, survival, differentiation, apoptosis or metastasis of the cancer cells. Several treatment approaches such as inhibition of oncomiRs and restoration of tumor suppressor miRNAs have been established in certain types of cancers and some other miRNA-based strategies are in development for cancer prevention and treatment. Nowadays, cancer is the most important target of miRNA therapeutics and the specific mechanisms by which miRNA mediates cancer pathways needs more research and study