Open Access“Electronic tongue” multi-systems for the separate determination of cefotaxime and cefazoline
Author(s) -
Е. Г. Кулапина,
Anastasia E. Dubasova,
О. И. Кулапина,
V. D. Ankina
Publication year - 2021
Publication title -
izvestiâ saratovskogo universiteta. novaâ seriâ. seriâ himiâ. biologiâ. èkologiâ
Language(s) - English
Resource type - Journals
eISSN - 2541-8971
pISSN - 1816-9775
DOI - 10.18500/1816-9775-2021-21-1-4-11
Subject(s) - electronic tongue , potentiometric titration , potentiometric sensor , electrode , sensitivity (control systems) , chemistry , analytical chemistry (journal) , materials science , biological system , chromatography , electronic engineering , engineering , food science , taste , biology
Electroanalytical properties of unmodified and modified by polyaniline and by CuO nanoparticles solid-contact potentiometric sensors which are based on associates of tetradecylammonium with complex compounds of silver (I) with cephuroxime, cephotaxime and cephazoline Ag(β-lac)2TDA in solutions of corresponding antibiotics were studied. It was revealed that Ag(β-lac)2TDA –based sensors had no specificity to the basic ion but showed sensitivity to other cephalosporins. Taking into account the potentiometric selectivity coefficients and cross-sensitivity parameters of sensors based on different electrode-active components, their use for creating «electronic tongue» multi-sensor systems was shown. Arrays of low-selective potentiometric sensors were created for separate determination of cephazoline and cephotaxime in two-component model mixtures at concentration intervals of 2,5·10-4 – 0,01 М. The method of artificial neural networks was used for processing analytical signals (the relative error of determination not exceeding 13%).