Open AccessAnalysis of Tumor Volume Dynamics in Colorectal Cancer
Author(s) -
А. А. Филин,
А. А. Сизов,
E.E. Chupandina,
В. И. Даниленко,
Д. Ю. Бугримов,
К. Г. Полупанова
Publication year - 2019
Publication title -
žurnal anatomii i gistopatologii
Language(s) - English
Resource type - Journals
ISSN - 2225-7357
DOI - 10.18499/2225-7357-2018-7-4-81-87
Subject(s) - colorectal cancer , life expectancy , stage (stratigraphy) , medicine , cancer , incidence (geometry) , disease , oncology , pathology , biology , population , paleontology , physics , environmental health , optics
The purpose of the study was to investigate the dynamics of tumor volume change in different age groups and its relation to the clinical (sex, age, stage of disease, life expectancy) and morphological parameters (tumor localization, metastases to regional lymph nodes, tumor invasion depth, histological type and degree of differentiation). Material and methods. The data of 527 patients (men and women, age from 24 to 86 years) suffering from colorectal cancer who underwent primary resection of the tumor. Clinical data and protocols of pathologist were analyzed: clinical stage of the disease, tumor localization, life expectancy, macroscopic, microscopic description, diagnosis. Based on the data obtained from the gross description, the tumor volume was calculated. Results . The maximum incidence of colorectal cancer was observed in patients in the age group from 70 to 79 years, more than 90% of all patients are over 50 years old. The volume of the tumor in colorectal cancer varied significantly, but the dynamics of the increase of the average volume with age was not observed. Opposite, the largest neoplasms were found in the youngest patients. Conclusion . Obtained data shows that changes in the tumor volume in colorectal cancer is nonlinear. Indicators of tumor volume in different age groups show similar dynamics: the most common tumors are mediumsized, but the small and very large tumors are much less common, which can explain the low rates of detection of tumors of this localization in the early stages.