Open AccessNeovasculogenesis stimulation is a new trend in the treatment of chronic arterial occlusive diseases of lower extremities
Author(s) -
Б. С. Суковатых,
Anzhelika Yur'evna Orlova
Publication year - 2011
Publication title -
vestnik èksperimentalʹnoj i kliničeskoj hirurgii
Language(s) - English
Resource type - Journals
eISSN - 2409-143X
pISSN - 2070-478X
DOI - 10.18499/2070-478x-2011-4-1-79-84
Subject(s) - medicine , microcirculation , ischemia , thigh , blood flow , limb ischemia , femoral artery , stimulation , platelet , surgery , cardiology , anesthesia
An analysis of experimental investigation of 70 male Vistar rates and results of examination and treatment of 30 patients suffered by chronic low limbs ischemia caused by atherosclerosis has been completed. All experimental animals were divided into three groups: healthy, control, and investigated respectively. A chronic limb ischemia was achieved by excision of the main vessel such as femoral, popliteal, and upper part of calf vessels. Having achieved an ischemia a treatment was not done in the control group. Whereas animals of the control group received injection of platelet enriched autoplasm into the calf and thigh muscles. It was discovered that intramascular injection of platelet enriched autoplasm into the animals ischemic limb increases microcirculation level 2,4 times and dicreases area of muscular necrosis by 2,4 times to 28 experimental day. In patients 500 ml of blood were derived, from which a platelet enriched plasma was made. 100 ml of the plasma were injected under ultrasound guidance along the deep femoral and popliteal arteries of the more 2nd b degree ischemic limb. A contralateral limb was used as a control group. After the treatment a blood flow volume was increased 1,4 times, main 885,08 in 1,3 times, and microcirculation level in 1,2 times.