Open AccessSeverity condition assessment in patients with intra-abdominal surgical infection
Author(s) -
Tatiana Petrovna Gvozdik,
В. С. Кононов,
Mazhit Akhmetovich Nurtelecom
Publication year - 2011
Publication title -
vestnik èksperimentalʹnoj i kliničeskoj hirurgii
Language(s) - English
Resource type - Journals
eISSN - 2409-143X
pISSN - 2070-478X
DOI - 10.18499/2070-478x-2011-4-1-45-50
Subject(s) - procalcitonin , medicine , sofa score , apache ii , gastroenterology , organ dysfunction , sepsis , concomitant , saps ii , severity of illness , bilirubin , surgery , intensive care unit
The therapy outcome of 258 patients with intra-abdominal surgical site infection has been evaluated, 205 (79,5%) of which developed abdominal sepsis of different severity degrees. In order to assess risk factors of lethal outcome, the severity of illness and related organ dysfunction scores have been calculated by means of APACHE II, SAPS, MODS и SOFA, as well as the procalcitonin levels test laboratory findings (PCT). In the present study, procalcitonin levels evaluation has shown to be a high sensitivity test that provides objective information for an infectious process assessment, correlating to APACHE II scores (R2=0,86). The concomitant liver dysfunction has been revealed be the most unfavorable factor for intra-abdominal infection prognosis, being the direct cause of death in 28,3% cases. The most sensitive values are total bilirubin, alkaline phosphatase, triglyceride levels, with the highest correlation ratio R2=0,92, R2=0,89, R2=0,93, respectively, which allows their application as an early diagnostic procedure for liver dysfunction detection in this group of patients with the perspectives of its correction.