Open AccessAn Old Drug for a New Application: Potential Benefits of Sildenafil in Wound Healing
Author(s) -
Shadi Farsaie,
Hossein Khalili,
Iman Karimzadeh,
Simin DashtiKhavidaki
Publication year - 2012
Publication title -
journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.497
H-Index - 78
ISSN - 1482-1826
DOI - 10.18433/j3tc7v
Subject(s) - sildenafil , medicine , wound healing , clinical trial , medline , animal studies , surgery , dermatology , intensive care medicine , political science , law
Purpose: Several studies have evaluated the effects of sildenafil on the tissue repair and wound healing. In the present review, the impact of sildenafil on the wound healing in all available clinical and non-clinical (experimental) studies has been discussed. Methods: A literature search was performed using PubMed, Scopus, Medline, Embase, Cochrane central register of controlled trials and Cochrane database systematic reviews. Related articles indexed in Google Scholar were also included. Key words used as search terms were ‘phosphodiesterase inhibitor’, ‘sildenafil’, ‘skin’, ‘cutaneous’, ‘skin lesion’, ‘skin damage’, ‘wound’, and ‘wound healing’. No time limitation was considered in this review. Results: A total of 15 animal studies, 7 case reports, and 2 small clinical studies have reported the effects of sildenafil on the wound healing. The effects included skin flaps and grafts, anastomosis, systemic sclerosis and Raynaud's disease. Conclusions: The available data support the beneficial effects of sildenafil in improvement of tissue healing in various conditions.
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