Open AccessPharmacokinetic of Diclofenac in the Presence and Absence of Glibenclamide in the Rat
Author(s) -
María R. León-Reyes,
Gilberto CastañedaHernández,
Mario I. Ortiz
Publication year - 2009
Publication title -
journal of pharmacy and pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.497
H-Index - 78
ISSN - 1482-1826
DOI - 10.18433/j3s597
Subject(s) - glibenclamide , diclofenac , pharmacokinetics , pharmacology , analgesic , pharmacodynamics , nociception , oral administration , medicine , drug interaction , chemistry , receptor , endocrinology , diabetes mellitus
There is evidence that the sulfonylurea antidiabetic agent glibenclamide reduces the analgesic action of non-steroidal anti-inflammatory drugs (NSAIDs), opioids and neuromodulators in animal models. Therefore, in view of the vast clinical uses and interactions of NSAIDs with commonly used therapeutic agents, the interaction of the NSAID diclofenac and glibenclamide was investigated about pharmacokinetic profile and antinociceptive effect in rats.